WWW Resources for Cytochrome P450 (CYP)
Sequence of CYP
The Cytochrome P-450 Enzymesystem
Adverse Effects and Drug Interactions
Comprehensive CYP metabolism lists
THE CYTOCHROME P-450 ENZYMESYSTEM
Abstracts from the most recent 30 days for "CYP metabolism" from PubMed
An review with many tables
A general article on drug metabolism that includes CYPs
Drug interactions of antidepressants in the elderly
A clinical article on CYP3As
A review article on clinical aspects of P450s
A general article on drug interactions and CYPs
Images of P450s; and P450 in relation to the brain and cocaine
Review of interactions between alcohol and drugs
Sserotonergic antidepressants from a pharmacists point of view
Drug interactions of newer atypical antipsychotics
P450 Protein family review article,Cytochromes P450: a success story,Daniele Werck-Reichhart1, Rene Feyereisen2
David Nelson's homepage:David Nelson keeps an update of P450 sequences characterized in all organisms and is also the'P450 nomenclature committee', the person to contact to obtain a name for a new P450 sequence. Nelson also provides a simple introductory lecture on mammalian P450 enzymes and on all their hysiological and other functions.
Home Page of the Human
Cytochrome P450 (CYP):Allele Nomenclature Committee An update of the knowledge on allelic variants of
the human genes; also provides instructions on the submission of new variants.
Directory of P450-containing systems:Lists P450 and related genes. More information on P450 structure, ligands, domain structure,electron donors and useful links on human alleles,drug metabolism, commercially available forms;also contains references.
The P450 site at the University of Arizona:A site with a list, annotation and a physical map of Drosophila and A. thaliana P450s.
in vitro drug metabolism methods or general information about cytochrome P450.
Crespi, CL, and VP Miller. 1999, Pharmacol. Ther., 84:121-131.
SE Clarke. 1998, Xenobiotica 28(12):1167-1202.
Shiraga, T, Kaneko, H, Iwasaki, K, Tozuka, Z, Suzuki, A, and T Hata. 1999, Xenobiotica 29(3): 217-229.
These papers review the RAF and RSF approach to designing experiments and interpreting data using cDNA-expressed enzymes.
Roy, P, Yu, LJ, Crespi, CL, and DJ Waxman. 1999, Drug Metab. Dispos. 27(6):655-666.
Nakajima, M, Nakamura, S, Tokudome, S, Shimada, N, Yamazaki, H, and Yokoi, T, (1999) Drug Metab. Dispos., 27, 1381-1391.
Crespi, CL and BW Penman, (1997) Adv. Pharmacol. 43, 171-188.
Cytochrome P450 Protocols.
Phillips, IR and EA Shepard, eds. 1998. Methods in Molecular Biology Vol. 107, Humana Press.
Gibson, GG and P Skett. 1994, Blackie Academic & Professional.
-- Metabolic and Toxicological Aspects
C Ioannides, ed. 1996, CRC Press.
-- Structure, Mechanism, and Biochemistry.
PR Ortiz de Montellano, ed. 1995, Plenum Press.
Drug Metabolism and Toxicology Links
Directory of P450-containing systems
Phase II Enzymes
free Medline database searching
Discussion and interactions table
PGPs in AIDS - discussion and interactions table
Drug Absorption / Metabolism
Abstracts from the most recent 30 days for "drug absorption" from PubMed
Abstracts from the most recent 30 days for "Conjugation" from PubMed