WWW Resources for Cytochrome P450 (CYP)


CYP Family

Sequence of CYP

CYP charts

The Cytochrome P-450 Enzymesystem

Drug Interactions

Adverse Effects and Drug Interactions

Comprehensive CYP metabolism lists

THE CYTOCHROME P-450 ENZYMESYSTEM@

FDA Medwatch  

Abstracts from the most recent 30 days for "CYP@metabolism" from PubMed

Gentest Corporation

 


Related Sites
An review with many tables

A general article on drug metabolism that includes CYPs

Drug interactions of antidepressants in the elderly

A clinical article on CYP3As

A review article on clinical aspects of P450s

A general article on drug interactions and CYPs

Images of P450s; and P450 in relation to the brain and cocaine

Review of interactions between alcohol and drugs

Sserotonergic antidepressants from a pharmacists point of view

Drug interactions of newer atypical antipsychotics


P450 Protein
P450 Protein family review article,Cytochromes P450: a success story,Daniele Werck-Reichhart1, Rene Feyereisen2

David Nelson's homepage:David Nelson keeps an update of P450 sequences characterized in all organisms and is also the'P450 nomenclature committee', the person to contact to obtain a name for a new P450 sequence. Nelson also provides a simple introductory lecture on mammalian P450 enzymes and on all their hysiological and other functions.

Home Page of the Human Cytochrome P450 (CYP):Allele Nomenclature Committee An update of the knowledge on allelic variants of
the human genes; also provides instructions on the submission of new variants.


Directory of P450-containing systems:Lists P450 and related genes. More information on P450 structure, ligands, domain structure,electron donors and useful links on human alleles,drug metabolism, commercially available forms;also contains references.

The P450 site at the University of Arizona:A site with a list, annotation and a physical map of Drosophila and A. thaliana P450s.


in vitro drug metabolism methods or general information about cytochrome P450. 

Journal Articles

Crespi, CL, and VP Miller. 1999, Pharmacol. Ther., 84:121-131.

SE Clarke. 1998, Xenobiotica 28(12):1167-1202.

Shiraga, T, Kaneko, H, Iwasaki, K, Tozuka, Z, Suzuki, A, and T Hata. 1999, Xenobiotica 29(3): 217-229.

These papers review the RAF and RSF approach to designing experiments and interpreting data using cDNA-expressed enzymes.

Roy, P, Yu, LJ, Crespi, CL, and DJ Waxman. 1999, Drug Metab. Dispos. 27(6):655-666. 

Nakajima, M, Nakamura, S, Tokudome, S, Shimada, N, Yamazaki, H, and Yokoi, T, (1999) Drug Metab. Dispos., 27, 1381-1391. 

Crespi, CL and BW Penman, (1997) Adv. Pharmacol. 43, 171-188.

Books

Cytochrome P450 Protocols.
Phillips, IR and EA Shepard, eds. 1998. Methods in Molecular Biology Vol. 107, Humana Press. 

Introduction to Drug Metabolism.
Gibson, GG and P Skett. 1994, Blackie Academic & Professional.

Cytochromes P450 -- Metabolic and Toxicological Aspects
C Ioannides, ed. 1996, CRC Press.

Cytochrome P450 -- Structure, Mechanism, and Biochemistry.
PR Ortiz de Montellano, ed. 1995, Plenum Press.

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Drug Metabolism and Toxicology Links

 

Conferences

Conferences in Drug Metabolism and Toxicology

Cytochrome P450

Directory of P450-containing systems
Human Cytochrome P450 (CYP) Allele Nomenclature Committee
Cytochrome P450 Homepage by Dr. David Nelson
P450 proteins in the PROMISE database
Cytochrome P450 Drug Interaction Table
A general introduction to cytochrome P450
Rogue's Gallery of P450 Researchers
People interested in P450 Research

Xenobiotic Transporters

Transporter homepage -- University of Groningen
European Study Group for Hepatobiliary Transport

Phase II Enzymes

UDP Glucuronosyltransferase (UGT) Home Page

Regulatory Agencies

FDA Home Page
FDA In Vitro Drug Metabolism Guide (Wait patiently for the pdf to download)

Scientific Societies

ISSX
AAPS Home Page

Toxicology

National Toxicology Program
National Center for Toxicology Research
Toxicology and Environmental Health Information

Scientific Literature

PubMed free Medline database searching
Drug Metabolism and Disposition homepage
Chemical Research in Toxicology homepage
Drug Metabolism Reviews homepage
Xenobiotica homepage
Pharmacogenetics homepage
In Vitro Drug Metabolism Literature
GENTEST Staff publications

Other Links

PharmCast Internet for the Pharmaceutical Community
Art and Liver -- A few masterpieces
Webmolecules 3D structures of many pharmaceuticals and toxins.



P-glycoproteins (PGP)

Discussion and interactions table

PGPs in AIDS - discussion and interactions table

Drug Absorption / Metabolism
Abstracts from the most recent 30 days for "drug absorption" from PubMed

Abstracts from the most recent 30 days for "Conjugation" from PubMed